BRLTTY supporte les synthèses vocales suivantes:
| Nom | Modèle |
| Alva | Delphi (4nn) |
| BrailleLite | |
| CombiBraille | |
| ExternalSpeech | exécute /usr/local/bin/externalspeech |
| Festival | text to speech engine |
| FestivalLite | text to speech engine |
| GenericSay | redirige vers /usr/local/bin/say |
| Mikropuhe | text to speech engine |
| Swift | text to speech engine |
| Theta | text to speech engine |
| ViaVoice | text to speech engine |