CD summary for pfam00035

CD:

pfam00035

Description:

dsrm, Double-stranded RNA binding motif. Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localization of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA.

CD status:

Full-length sequences, including 3D structure if known. Alignment from source, reindexed to representative

Source:

Pfam[US], Pfam[UK]

Created:

12-Sep-2001

References:

PubMed

Taxonomy spanned:

root ->

[ 81] from	cellular organisms
[ 7] from	Viruses

Aligned sequences:

Representative:

Consensus sequence:

Aligned range:

1-67

Sequence:

PKSALQELAQKRKLPLPEYELVEEEGPAHAPRFTVEVTVGGKTYFEGSGSSKKEAKQNAA
EAALRIL

This CD alignment includes 3D structure. To display structure, download Cn3D v3.0!

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FASTA with gaps
Phylip format
See ASN.1 file

Conservation color threshold:
Alignment width:

	3D	PDB-Id/gi	Definition
pick aligned sequences (will be added to selection above)
		1DI2 A	Xenopus laevis [CD]
		1QU6 A	Homo sapiens [CD]
		1EKZ A	Drosophila melanogaster [CD]
	7531276		RIBONUCLEASE III (RNASE III) [CD]
	7531197		RIBONUCLEASE III (RNASE III) [CD]
	1710609		RIBONUCLEASE III (RNASE III) [CD]
	7531189		RIBONUCLEASE III (RNASE III) [CD]
	7531188		RIBONUCLEASE III (RNASE III) [CD]
	7531275		RIBONUCLEASE III (RNASE III) [CD]
	2500554		RIBONUCLEASE III (RNASE III) [CD]
	6094109		RIBONUCLEASE III (RNASE III) [CD]
	2500555		HYPOTHETICAL 27.1 KDA PROTEIN SLR0346 [CD]
	2160163		Sequence of BAC F21M12 from Arabidopsis thaliana chromosome 1 [CD]
	2160163		Sequence of BAC F21M12 from Arabidopsis thaliana chromosome 1 [CD]
	1710608		RIBONUCLEASE III (RNASE III) [CD]
	1173093		RIBONUCLEASE III (RNASE III) [CD]
	133151		RIBONUCLEASE III (RNASE III) [CD]
	7531196		RIBONUCLEASE III (RNASE III) [CD]
	7531190		RIBONUCLEASE III (RNASE III) [CD]
	2500552		RIBONUCLEASE III (RNASE III) [CD]
	6226018		RIBONUCLEASE III (RNASE III) [CD]
	2500558		PUTATIVE RIBONUCLEASE III (RNASE III) [CD]
	7531193		RIBONUCLEASE III (RNASE III) [CD]
	7531191		RIBONUCLEASE III (RNASE III) [CD]
	2500556		PUTTIVE PROTEIN A464R [CD]
	2500553		RIBONUCLEASE III (RNASE III) [CD]
	3850247		Coltivirus JKT-7075 segment 8 Vp8 gene, complete cds [CD]
	458490		Caenorhabditis elegans chromosome III clone T20G5 [CD]
	458490		Caenorhabditis elegans chromosome III clone T20G5 [CD]
	3334379		TAR RNA-BINDING PROTEIN 2 (PROTAMINE-1 RNA BINDING PROTEIN) (PRM-1 RNA BINDING PROTEIN) [CD]
	3334379		TAR RNA-BINDING PROTEIN 2 (PROTAMINE-1 RNA BINDING PROTEIN) (PRM-1 RNA BINDING PROTEIN) [CD]
	3290198		Homo sapiens [CD]
	3290198		Homo sapiens [CD]
	3290198		Homo sapiens [CD]
	3334381		DOUBLE STRANDED RNA BINDING PROTEIN A (XLRBPA) [CD]
	9789804		DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG [CD]
	9789804		DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG [CD]
	1519659		Caenorhabditis elegans chromosome X clone F55A4 strain Bristol N2 [CD]
	1519659		Caenorhabditis elegans chromosome X clone F55A4 strain Bristol N2 [CD]
	1519663		Caenorhabditis elegans chromosome X clone F55A4 strain Bristol N2 [CD]
	1519663		Caenorhabditis elegans chromosome X clone F55A4 strain Bristol N2 [CD]
	1519663		Caenorhabditis elegans chromosome X clone F55A4 strain Bristol N2 [CD]
	1519663		Caenorhabditis elegans chromosome X clone F55A4 strain Bristol N2 [CD]
	134950		MATERNAL EFFECT PROTEIN STAUFEN [CD]
	134950		MATERNAL EFFECT PROTEIN STAUFEN [CD]
	134950		MATERNAL EFFECT PROTEIN STAUFEN [CD]
	134950		MATERNAL EFFECT PROTEIN STAUFEN [CD]
	532315		NF90 protein [CD]
	532315		NF90 protein [CD]
	2829669		DOUBLE-STRANDED RNA-SPECIFIC EDITASE 1 (DSRNA ADENOSINE DEAMINASE) (RNA EDITING ENZYME 1) [CD]
	2829669		DOUBLE-STRANDED RNA-SPECIFIC EDITASE 1 (DSRNA ADENOSINE DEAMINASE) (RNA EDITING ENZYME 1) [CD]
	1814270		Rattus norvegicus double-stranded RNA specific adenosine deaminase (RED2) mRNA, and translated products [CD]
	1814270		Rattus norvegicus double-stranded RNA specific adenosine deaminase (RED2) mRNA, and translated products [CD]
	7290203		Drosophila melanogaster chromosome X [CD]
	7290203		Drosophila melanogaster chromosome X [CD]
	125527		INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE (INTERFERON-INDUCIBLE RNA-DEPENDENT PROTEIN KINASE) (P68 KINASE) (P1/EIF-2A PROTEIN KINASE) [CD]
	2507204		INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE (INTERFERON-INDUCIBLE RNA-DEPENDENT PROTEIN KINASE) (P68 KINASE) (P1/EIF-2A PROTEIN KINASE) (SERINE/THREONINE-PROTEIN KINASE TIK) [CD]
	2507204		INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE (INTERFERON-INDUCIBLE RNA-DEPENDENT PROTEIN KINASE) (P68 KINASE) (P1/EIF-2A PROTEIN KINASE) (SERINE/THREONINE-PROTEIN KINASE TIK) [CD]
	468373		RNA-dependent initiation factor-2 kinase [CD]
	465071		PROTEIN E3 [CD]
	2984731		Orf virus interferon resistance determinant protein (OV20.0L) gene, complete cds; and RNA polymerase subunit homolog (OV20.3L) gene, partial cds [CD]
	673456		M.musculus Tenr mRNA for RNA binding protein, and translated products [CD]
	1706532		DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE (DRADA) (136 KDA DOUBLE-STRANDED RNA BINDING PROTEIN) (P136) (K88DSRBP) [CD]
	1706532		DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE (DRADA) (136 KDA DOUBLE-STRANDED RNA BINDING PROTEIN) (P136) (K88DSRBP) [CD]
	1706532		DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE (DRADA) (136 KDA DOUBLE-STRANDED RNA BINDING PROTEIN) (P136) (K88DSRBP) [CD]
	1932813		Xenopus laevis dsRNA adenosine deaminase (dsRAD-1) mRNA, and translated products [CD]
	1932813		Xenopus laevis dsRNA adenosine deaminase (dsRAD-1) mRNA, and translated products [CD]
	586013		SON PROTEIN (SON3) [CD]
	465898		HYPOTHETICAL HELICASE K12H4.8 IN CHROMOSOME III [CD]
	4490937		Homo sapiens mRNA for hypothetical helicase K12H4.8-like protein, partial, and translated products [CD]
	2500557		RIBONUCLEASE III (RNASE III) [CD]
	1350789		60S RIBOSOMAL PROTEIN L3, MITOCHONDRIAL PRECURSOR (YML3) [CD]
	2668620		Acyrthosiphon pisum virus protein P1 gene, complete cds; and protein P2 gene, partial cds [CD]
	3850201		Coltivirus JKT-6423 vp12 gene, complete cds [CD]
	129540		DOUBLE-STRAND-SPECIFIC PAC1 RIBONUCLEASE (HCS PROTEIN) [CD]
	2388673		Drosophila C virus strain EB, complete genome [CD]
	3913434		ATP-DEPENDENT RNA HELICASE A (NUCLEAR DNA HELICASE II) (NDH II) (DEAD-BOX PROTEIN 9) (MHEL-5) [CD]
	3913434		ATP-DEPENDENT RNA HELICASE A (NUCLEAR DNA HELICASE II) (NDH II) (DEAD-BOX PROTEIN 9) (MHEL-5) [CD]
	3650397		Sciara ocellaris [CD]
	3650397		Sciara ocellaris [CD]
	127156		DOSAGE COMPENSATION REGULATOR (MALE-LESS PROTEIN) (NO ACTION POTENTIAL PROTEIN) [CD]
	127156		DOSAGE COMPENSATION REGULATOR (MALE-LESS PROTEIN) (NO ACTION POTENTIAL PROTEIN) [CD]
	3913436		PROBABLE ATP-DEPENDENT RNA HELICASE A (NUCLEAR DNA HELICASE II) (NDH II) [CD]
	3913436		PROBABLE ATP-DEPENDENT RNA HELICASE A (NUCLEAR DNA HELICASE II) (NDH II) [CD]
	466149		HYPOTHETICAL 80.5 KD PROTEIN ZK632.2 IN CHROMOSOME III [CD]
	3283023		Caenorhabditis elegans putative RNA adenosine deaminase mRNA, complete cds [CD]
	12643664		DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG [CD]
	3334380		TAR RNA-BINDING PROTEIN 2 (TRANS-ACTIVATION RESPONSIVE RNA-BINDING PROTEIN) [CD]